Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 24 January 2006
Vol. 2006, Issue 319, p. tw33
[DOI: 10.1126/stke.3192006tw33]


VIROLOGY Rho, Rho, Rho Your Vaccinia

Viruses subvert a variety of host cell mechanisms during infection, replication, and dissemination. Valderrama et al. now describe how vaccinia virus promotes cellular motility by interfering with the activity of RhoA, a small guanosine triphosphase-binding protein involved in intracellular signaling, which particularly affects the actin cytoskeleton. A conserved vaccinia protein, F11L, directly interacts with RhoA, mimicking one of its endogenous substrates, ROCK, and inducing cellular motility. The induced motility is likely to facilitate the spread of the virus within tissues.

F. Valderrama, J. V. Cordeiro, S. Schleich, F. Frischknecht, M. Way, Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling. Science 311, 377-381 (2006). [Abstract] [Full Text]

Citation: Rho, Rho, Rho Your Vaccinia. Sci. STKE 2006, tw33 (2006).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882