Sci. STKE, 24 January 2006
VIROLOGY Rho, Rho, Rho Your Vaccinia
Viruses subvert a variety of host cell mechanisms during infection, replication, and dissemination. Valderrama et al. now describe how vaccinia virus promotes cellular motility by interfering with the activity of RhoA, a small guanosine triphosphase-binding protein involved in intracellular signaling, which particularly affects the actin cytoskeleton. A conserved vaccinia protein, F11L, directly interacts with RhoA, mimicking one of its endogenous substrates, ROCK, and inducing cellular motility. The induced motility is likely to facilitate the spread of the virus within tissues.
F. Valderrama, J. V. Cordeiro, S. Schleich, F. Frischknecht, M. Way, Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling. Science 311, 377-381 (2006). [Abstract] [Full Text]
Citation: Rho, Rho, Rho Your Vaccinia. Sci. STKE 2006, tw33 (2006).
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