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Sci. STKE, 31 January 2006
Vol. 2006, Issue 320, p. re1
[DOI: 10.1126/stke.3202006re1]


Inhibition of Immune Responses by ITAM-Bearing Receptors

Jessica A. Hamerman and Lewis L. Lanier*

Department of Microbiology and Immunology and the Cancer Research Institute, University of California at San Francisco, 513 Parnassus Avenue, Box 0414, HSE1001, San Francisco, CA 94143–0414, USA.

Abstract: Cells of the immune system possess many multisubunit receptors that are composed of a ligand-binding subunit associated with distinct signaling adaptors containing one or more immunoreceptor tyrosine-based activation motifs (ITAMs). These receptors include the T cell receptor, the B cell receptor, and many Fc receptors, as well as families of activating receptors on myeloid and natural killer cells. Receptors that associate with ITAM-containing adaptors classically have been viewed as transducing activating signals involving phosphorylation of the tyrosines within the ITAM and recruitment of Syk family tyrosine kinases. Receptors associated with ITAM-containing adaptors in myeloid cells have also been implicated in inhibition of cellular activation. Here, we discuss these new negative roles for signaling by receptors that associate with ITAM-bearing adaptors in myeloid and other cell types within the immune system.

*Corresponding author. E-mail, lewis.lanier{at}

Citation: J. A. Hamerman, L. L. Lanier, Inhibition of Immune Responses by ITAM-Bearing Receptors. Sci. STKE 2006, re1 (2006).

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