Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 7 February 2006
Vol. 2006, Issue 321, p. tw54
[DOI: 10.1126/stke.3212006tw54]

EDITORS' CHOICE

NEUROBIOLOGY Neurons Navigate Downstream

Neurons born near the brain's ventricles travel out to the olfactory bulb to function in olfaction. A steady stream of migrating neurons makes the journey not only in early development but also during adulthood. Sawamoto et al. now provide insight into how these neurons find their way in mice. The ventricles of the brain are lined with cells bearing cilia on their surface. The coordinated beating of these cilia develops a stream of fluid coursing through the ventricles carrying signaling factors that guide the traveling neurons. Mutations that disrupt the cilia also disrupt establishment of the signaling gradient and the migration of the neurons to the olfactory bulb.

K. Sawamoto, H. Wichterle, O. Gonzalez-Perez, J. A. Cholfin, M. Yamada, N. Spassky, N. S. Murcia, J. M. Garcia-Verdugo, O. Marin, J. L. R. Rubenstein, M. Tessier-Lavigne, H. Okano, A. Alvarez-Buylla, New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 311, 629-632 (2006). [Abstract] [Full Text]

Citation: Neurons Navigate Downstream. Sci. STKE 2006, tw54 (2006).

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)