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Sci. STKE, 14 February 2006
Vol. 2006, Issue 322, p. cm2
[DOI: 10.1126/stke.3222006cm2]

CONNECTIONS MAP OVERVIEWS

Jasmonate Signaling Pathway

Robin Liechti, Aurélie Gfeller, and Edward E. Farmer*

Gene Expression Laboratory, Plant Molecular Biology, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.

stkecm;CMP_13820

Abstract: Jasmonates in plants are cyclic fatty acid–derived regulators structurally similar to prostaglandins in metazoans. These chemicals mediate many of plants' transcriptional responses to wounding and pathogenesis by acting as potent regulators for the expression of numerous frontline immune response genes, including those for defensins and antifungal proteins. Additionally, the pathway is critical for fertility. Ongoing genetic screens and protein-protein interaction assays are identifying components of the canonical jasmonate signaling pathway. A massive molecular machine, based on two multiprotein complexes, SCFCOI1 and the COP9 signalosome (CNS), plays a central role in jasmonate signaling. This machine functions in vivo as a ubiquitin ligase complex, probably targeting regulatory proteins, some of which are expected to be transcriptional repressors. Some defense-related mediators, notably salicylic acid, antagonize jasmonates in controlling the expression of many genes. In Arabidopsis, NONEXPRESSOR OF PR GENES (NPR1) mediates part of this interaction, with another layer of control provided further downstream by the mitogen-activated protein kinase (MAPK) homolog MPK4. Numerous other interpathway connections influence the jasmonate pathway. Insights from Arabidopsis have shown that an allele of the auxin signaling gene AXR1, for example, reduces the sensitivity of plants to jasmonate. APETALA2 (AP2)-domain transcription factors, such as ETHYLENE RESPONSE FACTOR 1 (ERF1), link the jasmonate pathway to the ethylene signaling pathway. As progress in characterizing several new mutants (some of which are hypersensitive to jasmonic acid) augments our understanding of jasmonate signaling, the Connections Map will be updated to include this new information.

*Corresponding author. E-mail, edward.farmer{at}unil.ch

Citation: R. Liechti, A. Gfeller, E. E. Farmer, Jasmonate Signaling Pathway. Sci. STKE 2006, cm2 (2006).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The PP2C-Type Phosphatase AP2C1, Which Negatively Regulates MPK4 and MPK6, Modulates Innate Immunity, Jasmonic Acid, and Ethylene Levels in Arabidopsis.
A. Schweighofer, V. Kazanaviciute, E. Scheikl, M. Teige, R. Doczi, H. Hirt, M. Schwanninger, M. Kant, R. Schuurink, F. Mauch, et al. (2007)
PLANT CELL 19, 2213-2224
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