Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 14 February 2006
Vol. 2006, Issue 322, p. tw61
[DOI: 10.1126/stke.3222006tw61]

EDITORS' CHOICE

EVOLUTION Basic Body Design

Why have certain features of animal body plans, such as bilateral symmetry, been conserved since the early Cambrian period, whereas at the species level, there has been a continuous accumulation of changes? Davidson and Erwin propose that the genetic regulatory networks associated with development contain three components that differ in their evolutionary conservation. Evolutionarily inflexible subcircuits ("kernels") perform essential upstream functions in building given body parts, while other small subcircuits ("plug-ins") have been repeatedly coopted to diverse developmental purposes, leaving highly flexible, individual cis-regulatory linkages to regulate detailed phenotypic variation.

E. H. Davidson, D. H. Erwin, Gene regulatory networks and the evolution of animal body plans. Science 311, 796-800 (2006). [Abstract] [Full Text]

Citation: Basic Body Design. Sci. STKE 2006, tw61 (2006).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882