Sci. STKE, 14 March 2006
GENETICS Extending Genetic Interaction Maps
Although there are elegant interaction maps available for yeast and Drosophila, it will become more difficult to find complete, high-quality data for higher organisms. Zhong and Sternberg (see the Perspective by Eddy) have developed a computational approach to cross-species data integration and have used it to generate a map of Caenorhabditis elegans genetic interactions. To test the robustness of their predictions, RNA interference analysis was used to verify novel interactors predicted for let-60 and itr-1.
Citation: Extending Genetic Interaction Maps. Sci. STKE 2006, tw96 (2006).
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