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Sci. STKE, 4 April 2006 PERSPECTIVESShedding Light on the Distinct Functions of ProteoglycansThe Developmental Biology Center, and Departments of Pediatrics and Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA. Summary: Heparan sulfate proteoglycans (HSPGs) are ubiquitous molecules that are critical for signaling mediated by many growth factors, including members of the Wnt, transforming growth factor–ß, Hedgehog, and fibroblast growth factor families, and are essential for cell specification, axon guidance, and the establishment of morphogen gradients. Although the heparan sulfate modifications of HSPGs are critical, there is much to learn about how the protein cores contribute to the specific signaling functions of these cell-surface and matrix molecules. Recent work has demonstrated that glypican-1 and syndecan-1 expressed by tumor cells have specific roles in FGF2 signaling, affecting their responses to this mitogenic stimulus. *Corresponding author. E-mail, selle011{at}umn.edu
Citation: S. B. Selleck, Shedding Light on the Distinct Functions of Proteoglycans. Sci. STKE 2006, pe17 (2006). The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
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