Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 4 April 2006
Vol. 2006, Issue 329, p. tw116
[DOI: 10.1126/stke.3292006tw116]


IMMUNOLOGY Shared Signals

The immune system is classically described in terms of innate and acquired immunity, although it is becoming increasingly apparent that these two arms share some fundamental cellular and molecular processes. In large part, this overlap exists "downstream" at points of gene expression and transcriptional regulation; for example, the transcription factor NF-{kappa}B activates a large number of innate and acquired immune response genes. Although "upstream" (membrane proximal) signaling proteins appear to be more segregated, Suzuki et al. find that IRAK-4, a dominant protein kinase already known to be involved in signaling innate immune responses from Toll-like receptors, also supports signaling from the T cell receptor. Thus, mice lacking the IRAK-4 gene showed diminished acquired T cell immunity to viral infection.

N. Suzuki, S. Suzuki, D. G. Millar, M. Unno, H. Hara, T. Calzascia, S. Yamasaki, T. Yokosuka, N.-J. Chen, A. R. Elford, J.-i. Suzuki, A. Takeuchi, C. Mirtsos, D. Bouchard, P. S. Ohashi, W.-C. Yeh, T. Saito, A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science 311, 1927-1932 (2006). [Abstract] [Full Text]

Citation: Shared Signals. Sci. STKE 2006, tw116 (2006).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882