Sci. STKE, 4 April 2006
IMMUNOLOGY Accentuate the Positive
The cytokine interleukin-2 (IL-2) facilitates proliferation of naïve T cells, but several studies have shown that antibodies that bind IL-2, which at first glance should be inhibitory, can promote the expansion of subsets of memory CD8+ T cells. Thus, IL-2 might somehow be inhibiting suppressive T cell populations that would otherwise prevent memory CD8+ T cell expansion. Boyman et al. (see the Perspective by Prlic and Bevan) now show that, instead, binding of antibodies to IL-2 augments the direct activity of the cytokine on memory CD8+ T cells themselves. Immune complexes form that focus local levels of IL-2 through presentation by Fc receptors. These observations could be important to consider in therapies that involve the manipulation of IL-2 and other cytokines, such as bone marrow transplantation and tumor immunotherapy.
Citation: Accentuate the Positive. Sci. STKE 2006, tw117 (2006).
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