Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 11 April 2006
Vol. 2006, Issue 330, p. tw124
[DOI: 10.1126/stke.3302006tw124]

EDITORS' CHOICE

PHYSIOLOGY Serotonin and Liver Regeneration

The liver can regenerate after severe injury or surgery, even when up to 70% of the tissue has been removed. Lesurtel et al. report that in a mouse model, serotonin carried by platelets circulating in the blood plays a role in the regenerative process. Liver was found to express serotonin receptors. Mice with impaired platelet function had a reduced regenerative response, but when they were treated with a serotonin receptor agonist, hepatocyte proliferation was restored. Liver regeneration in mice lacking peripheral serotonin was also restored when their platelets were reloaded with serotonin. Therapeutic treatment with serotonin receptor agonists may thus be useful in tissue recovery.

M. Lesurtel, R. Graf, B. Aleil, D. J. Walther, Y. Tian, W. Jochum, C. Gachet, M. Bader, P.-A. Clavien, Platelet-derived serotonin mediates liver regeneration. Science 312, 104-107 (2006). [Abstract] [Full Text]

Citation: Serotonin and Liver Regeneration. Sci. STKE 2006, tw124 (2006).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882