Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 25 April 2006
Vol. 2006, Issue 332, p. re3
[DOI: 10.1126/stke.3322006re3]


Reactive Oxygen Species–Mediated Mitochondria-to-Nucleus Signaling: A Key to Aging and Radical-Caused Diseases

Peter Storz*

Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Abstract: Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.

*Corresponding author. E-mail: storz.peter{at}

Citation: P. Storz, Reactive Oxygen Species–Mediated Mitochondria-to-Nucleus Signaling: A Key to Aging and Radical-Caused Diseases. Sci. STKE 2006, re3 (2006).

Read the Full Text

FOXO3 determines the accumulation of {alpha}-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.
E. Pino, R. Amamoto, L. Zheng, M. Cacquevel, J.-C. Sarria, G. W. Knott, and B. L. Schneider (2014)
Hum. Mol. Genet. 23, 1435-1452
   Abstract »    Full Text »    PDF »
Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis.
J. L. Sartoretto, H. Kalwa, M. D. Pluth, S. J. Lippard, and T. Michel (2011)
PNAS 108, 15792-15797
   Abstract »    Full Text »    PDF »
ROS-induced ROS release in vascular biology: redox-redox signaling.
N. S. Zinkevich and D. D. Gutterman (2011)
Am J Physiol Heart Circ Physiol 301, H647-H653
   Abstract »    Full Text »    PDF »
Cardiolipin: characterization of distinct oxidized molecular species.
J. Kim, P. E. Minkler, R. G. Salomon, V. E. Anderson, and C. L. Hoppel (2011)
J. Lipid Res. 52, 125-135
   Abstract »    Full Text »    PDF »
Mitochondrial Complex II Prevents Hypoxic but Not Calcium- and Proapoptotic Bcl-2 Protein-induced Mitochondrial Membrane Potential Loss.
B. J. Hawkins, M. D. Levin, P. J. Doonan, N. B. Petrenko, C. W. Davis, V. V. Patel, and M. Madesh (2010)
J. Biol. Chem. 285, 26494-26505
   Abstract »    Full Text »    PDF »
Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism.
J. Strathmann, K. Klimo, S. W. Sauer, J. G. Okun, J. H. M. Prehn, and C. Gerhauser (2010)
FASEB J 24, 2938-2950
   Abstract »    Full Text »    PDF »
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species.
N. Bashan, J. Kovsan, I. Kachko, H. Ovadia, and A. Rudich (2009)
Physiol Rev 89, 27-71
   Abstract »    Full Text »    PDF »
Molecular bases of progeroid syndromes.
C. L. Navarro, P. Cau, and N. Levy (2006)
Hum. Mol. Genet. 15, R151-R161
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882