Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 25 April 2006
Vol. 2006, Issue 332, p. tw142
[DOI: 10.1126/stke.3322006tw142]

EDITORS' CHOICE

INNATE IMMUNITY RNA Interference with Viruses

RNA interference (RNAi) plays a role in the defense against viral infection in plants, but does it play a similar role in animals? The evidence from tissue culture cells and Caenorhabditis elegans-based systems has suggested that this is so, but definitive evidence in a system that uses endogenous viruses and whole animals has been lacking. Wang et al. now show that both Drosophila embryos and adult flies mount a substantial innate immune response to insect viruses that requires the RNAi machinery and that this innate defense is separable from the innate bacterial defense provided by the Toll and immune-deficiency pathways.

X.-H. Wang, R. Aliyari, W.-X. Li, H.-W. Li, K. Kim, R. Carthew, P. Atkinson, S.-W. Ding, RNA interference directs innate immunity against viruses in adult Drosophila. Science 312, 452-454 (2006). [Abstract] [Full Text]

Citation: RNA Interference with Viruses. Sci. STKE 2006, tw142 (2006).

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)