Sci. STKE, 2 May 2006
PHARMACOLOGY Botox Receptor
Botulinum neurotoxin A (BoNT/A) is one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A has a long half-life within cells and is widely used in the treatment of conditions ranging from wrinkles to chronic pain. Moreover, BoNT/A can cause paralysis that persists for months. BoNT/A is known to block neurotransmission by cleaving the protein SNAP-25 in presynaptic terminals, but it is not clear how this toxin selectively recognizes and enters neurons. Dong et al. now identify a protein component of the cellular receptor for BoNT/A as a synaptic vesicle protein, SV2. BoNT/A enters neurons via recycling synaptic vesicles by binding to SV2 isoforms, and cells and animals lacking SV2 are resistant to intoxication.
Citation: Botox Receptor. Sci. STKE 2006, tw150 (2006).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882