Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 16 May 2006
Vol. 2006, Issue 335, p. eg7
[DOI: 10.1126/stke.3352006eg7]


Focus Issue: Viruses—Miniature Machiavellis of the Signaling World?

Elizabeth M. Adler*

Associate Editor of Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This week’s issue of Science’s STKE, published in conjunction with a Special Issue of Science on virology, describes viral mechanisms for manipulating signaling pathways in the host cell to ensure their own replication and survival. Münter et al. focus on how viruses and other pathogens manipulate tyrosine kinase- and Rho guanosine triphosphatase-mediated pathways; Barry and Früh discuss how viruses manipulate cullin RING ubiquitin ligases to evade host defenses; and Hayward et al. compare mechanisms whereby Epstein-Barr virus (EBV) and Kaposi's sarcoma associated herpesviruses (KSHV) interact with the Wnt and Notch signaling pathways. In a Review in Science, García-Sastre and Biron discuss the interplay between virus offenses and host defenses, focusing on the role of the type I interferons.

*Contact information. E-mail: eadler{at}

Citation: E. M. Adler, Focus Issue: Viruses—Miniature Machiavellis of the Signaling World? Sci. STKE 2006, eg7 (2006).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882