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Sci. STKE, 16 May 2006
Vol. 2006, Issue 335, p. pe21
[DOI: 10.1126/stke.3352006pe21]


Viral Modulators of Cullin RING Ubiquitin Ligases: Culling the Host Defense

Michele Barry1 and Klaus Früh2*

1Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
2Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA.

Abstract: Cullin RING ubiquitin ligases (CRULs) are found in all eukaryotes and play an essential role in targeting proteins for ubiquitin-mediated destruction, thus regulating a plethora of cellular processes. Viruses manipulate CRULs by redirecting this destruction machinery to eliminate unwanted host cell proteins, thus allowing viruses to slip past host immune barriers. Depending on the host organism, virus-modified CRULs can perform an amazing range of tasks, including the elimination of crucial signal transduction molecules in the human interferon pathway and suppression of virus-induced gene silencing in plants. This Perspective summarizes recent advances in our understanding of how viral proteins manipulate the function of CRULs.

*Corresponding author. E-mail, fruehk{at}

Citation: M. Barry, K. Früh, Viral Modulators of Cullin RING Ubiquitin Ligases: Culling the Host Defense. Sci. STKE 2006, pe21 (2006).

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