Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 23 May 2006
Vol. 2006, Issue 336, p. pe22
[DOI: 10.1126/stke.3362006pe22]

PERSPECTIVES

Second Messenger Pas de Deux: The Coordinated Dance Between Calcium and cAMP

Laura N. Borodinsky* and Nicholas C. Spitzer

Neurobiology Section and Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract: Dynamic calcium signaling is a well-established precept in biology. Different cell types exhibit spontaneous as well as stimulus-triggered transient changes in the concentration of intracellular calcium. Does this behavior extend to other second messengers? Optical dissection of various signal transduction pathways with fluorescent reporter molecules that enable visualization of changes in concentration of other second messengers is well under way. Recent research using technologically refined probes provides improved temporal and spatial resolution of adenosine 3',5'-monophosphate (cAMP) dynamics to generate insights into the bidirectional interplay between intracellular fluctuations of cAMP and calcium. cAMP oscillations are generated in response to hormones, and cells can recognize and differentially respond to transient versus sustained changes in this second messenger. Second messenger reporters are now available to track multiple players and so provide a dynamic picture of signaling networks.

*Corresponding author. E-mail: lborodin{at}biomail.ucsd.edu

Citation: L. N. Borodinsky, N. C. Spitzer, Second Messenger Pas de Deux: The Coordinated Dance Between Calcium and cAMP. Sci. STKE 2006, pe22 (2006).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Multiplexed Fluorescent Assay for Independent Second-Messenger Systems: Decoding GPCR Activation in Living Cells.
P. H. Tewson, A. M. Quinn, and T. E. Hughes (2013)
J Biomol Screen 18, 797-806
   Abstract »    Full Text »    PDF »
Role of Ion Channels and Transporters in Cell Migration.
A. Schwab, A. Fabian, P. J. Hanley, and C. Stock (2012)
Physiol Rev 92, 1865-1913
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882