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Sci. STKE, 23 May 2006
Vol. 2006, Issue 336, p. pe22
Second Messenger Pas de Deux: The Coordinated Dance Between Calcium and cAMP
Laura N. Borodinsky* and
Nicholas C. Spitzer
Neurobiology Section and Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92093, USA.
Dynamic calcium signaling is a well-established precept in biology. Different cell types exhibit spontaneous as well as stimulus-triggered transient changes in the concentration of intracellular calcium. Does this behavior extend to other second messengers? Optical dissection of various signal transduction pathways with fluorescent reporter molecules that enable visualization of changes in concentration of other second messengers is well under way. Recent research using technologically refined probes provides improved temporal and spatial resolution of adenosine 3',5'-monophosphate (cAMP) dynamics to generate insights into the bidirectional interplay between intracellular fluctuations of cAMP and calcium. cAMP oscillations are generated in response to hormones, and cells can recognize and differentially respond to transient versus sustained changes in this second messenger. Second messenger reporters are now available to track multiple players and so provide a dynamic picture of signaling networks.
Elizabeth M. Adler (3 August 2010) Sci. Signal.3 (133), ec238.
[DOI: 10.1126/scisignal.3133ec238] |Abstract »
Nancy R. Gough and John F. Foley (28 July 2009) Sci. Signal.2 (81), eg10.
[DOI: 10.1126/scisignal.281eg10] |Abstract »|Full Text »|PDF »
Mark C. Harbeck, Oleg Chepurny, Viacheslav O. Nikolaev, Martin J. Lohse, George G. Holz, and Michael W. Roe (19 September 2006) Sci. STKE2006 (353), pl6.
[DOI: 10.1126/stke.3532006pl6] |Abstract »|Full Text »|PDF »