Sci. STKE, 20 June 2006
NEUROSCIENCE Inflammation, Amplification, and Aggravation
Many details about how inflammatory pain is amplified at the spinal dorsal horn have been uncovered in recent years, but a unifying cellular model is still missing. Ikeda et al. identified a synaptic pain amplifier that is turned on by low-frequency conditioning stimulation and by natural noxious stimulation. In vivo, a low-frequency afferent barrage can raise Ca2+ concentration in nociceptive spinal cord neurons sufficiently to induce long-term potentiation. This process causes amplification of pain-related information at the first synapse in pain pathways.
Citation: Inflammation, Amplification, and Aggravation. Sci. STKE 2006, tw209 (2006).
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