Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 27 June 2006
Vol. 2006, Issue 341, p. tw216
[DOI: 10.1126/stke.3412006tw216]


NEUROSCIENCE Dok-7 Building the Synapse

The synapse between motor neurons and skeletal muscles forms during development when the neuron contacts the muscle and secretes a protein called agrin. Agrin, in turn, causes phosphorylation of a muscle-specific receptor kinase, MuSK, ultimately resulting in clustering of acetylcholine receptors on the muscle membrane at the site of nerve contact. Okada et al. now describe Dok-7, a protein that can bypass the requirement for agrin and that is required for MuSK activation, binding to and activating MuSK through a PTB domain. Mice engineered to lack Dok-7 do not form clusters of neurotransmitter receptors, and a mutant form of Dok-7 found in patients with congenital myasthenic syndrome prevents normal receptor clustering and junction formation. Thus, Dok-7 is a MuSK binding protein required for the formation of the postsynaptic side of the neuromuscular junction.

K. Okada, A. Inoue, M. Okada, Y. Murata, S. Kakuta, T. Jigami, S. Kubo, H. Shiraishi, K. Eguchi, M. Motomura, T. Akiyama, Y. Iwakura, O. Higuchi, Y. Yamanashi, The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science 312, 1802-1805 (2006). [Abstract] [Full Text]

Citation: Dok-7 Building the Synapse. Sci. STKE 2006, tw216 (2006).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882