Receptors as Microprocessors: Pharmacological Nuance on Metabotropic Glutamate Receptors 1{alpha}

doi:10.1126/stke.3422006pe29

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Sci. STKE, 3 July 2006
Vol. 2006, Issue 342, p. pe29
[DOI: 10.1126/stke.3422006pe29]

PERSPECTIVES

Receptors as Microprocessors: Pharmacological Nuance on Metabotropic Glutamate Receptors 1 ${alpha}$

Terry Kenakin^*

Assay Development, GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709, USA.

Summary: G protein–coupled receptors have revealed themselves to be complex information-processing units that may be exploited for subtle therapeutic signaling effects. Thus, ligands may not only turn receptors on and off, but may also select from their repertoire of signaling effects to further refine drug response.

*E-mail, terry.p.kenakin{at}gsk.com

Citation: T. Kenakin, Receptors as Microprocessors: Pharmacological Nuance on Metabotropic Glutamate Receptors 1 ${alpha}$ . Sci. STKE 2006, pe29 (2006).

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