Sci. STKE, 3 July 2006
Receptors as Microprocessors: Pharmacological Nuance on Metabotropic Glutamate Receptors 1α
Assay Development, GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709, USA.
Abstract: G protein–coupled receptors have revealed themselves to be complex information-processing units that may be exploited for subtle therapeutic signaling effects. Thus, ligands may not only turn receptors on and off, but may also select from their repertoire of signaling effects to further refine drug response.
Citation: T. Kenakin, Receptors as Microprocessors: Pharmacological Nuance on Metabotropic Glutamate Receptors 1α. Sci. STKE 2006, pe29 (2006).
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