Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 11 July 2006
Vol. 2006, Issue 343, p. pe30
[DOI: 10.1126/stke.3432006pe30]

Touched and Moved by STAT3

S. Paul Gao and Jacqueline F. Bromberg*

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Abstract: STAT3, a member of the signal transducer and activator of transcription (STAT) family of transcription factors, is a known regulator of cell motility through its transcriptional activating functions. However, new evidence suggests a novel role for non–tyrosine-phosphorylated and cytoplasmically localized STAT3 in mediating cell migration by disrupting an interaction between microtubules and one of its partners, stathmin. The association of STAT3 with stathmin potentiates microtubule polymerization and cell movement.

*Corresponding author. E-mail, bromberj{at}mskcc.org

Citation: S. P. Gao, J. F. Bromberg, Touched and Moved by STAT3. Sci. STKE 2006, pe30 (2006).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Curcumin Suppresses Vasculogenic Mimicry Capacity of Hepatocellular Carcinoma Cells through STAT3 and PI3K/AKT Inhibition.
K. CHIABLAEM, K. LIRDPRAPAMONGKOL, S. KEERATICHAMROEN, R. SURARIT, and J. SVASTI (2014)
Anticancer Res 34, 1857-1864
   Abstract »    Full Text »    PDF »
Targeting cell motility in pulmonary arterial hypertension.
R. Paulin, J. Meloche, A. Courboulin, C. Lambert, A. Haromy, A. Courchesne, P. Bonnet, S. Provencher, E. D. Michelakis, and S. Bonnet (2014)
Eur. Respir. J. 43, 531-544
   Abstract »    Full Text »    PDF »
Indirubin Derivative 6BIO Suppresses Metastasis.
S. Braig, C. A. Kressirer, J. Liebl, F. Bischoff, S. Zahler, L. Meijer, and A. M. Vollmar (2013)
Cancer Res. 73, 6004-6012
   Abstract »    Full Text »    PDF »
STAT3 Protein Interacts with Class O Forkhead Transcription Factors in the Cytoplasm and Regulates Nuclear/Cytoplasmic Localization of FoxO1 and FoxO3a Proteins in CD4+ T Cells.
H.-M. Oh, C.-R. Yu, I. Dambuza, B. Marrero, and C. E. Egwuagu (2012)
J. Biol. Chem. 287, 30436-30443
   Abstract »    Full Text »    PDF »
6-Bromoindirubin-3'-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells.
L. Liu, S. Nam, Y. Tian, F. Yang, J. Wu, Y. Wang, A. Scuto, P. Polychronopoulos, P. Magiatis, L. Skaltsounis, et al. (2011)
Cancer Res. 71, 3972-3979
   Abstract »    Full Text »    PDF »
Doubles Game: Src-Stat3 versus p53-PTEN in Cellular Migration and Invasion.
U. K. Mukhopadhyay, P. Mooney, L. Jia, R. Eves, L. Raptis, and A. S. Mak (2010)
Mol. Cell. Biol. 30, 4980-4995
   Abstract »    Full Text »    PDF »
Upregulation of STAT3 Marks Burkitt Lymphoma Cells Refractory to Epstein-Barr Virus Lytic Cycle Induction by HDAC Inhibitors.
D. Daigle, C. Megyola, A. El-Guindy, L. Gradoville, D. Tuck, G. Miller, and S. Bhaduri-McIntosh (2010)
J. Virol. 84, 993-1004
   Abstract »    Full Text »    PDF »
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.
M. Pang, J. Kothapally, H. Mao, E. Tolbert, M. Ponnusamy, Y. E. Chin, and S. Zhuang (2009)
Am J Physiol Renal Physiol 297, F996-F1005
   Abstract »    Full Text »    PDF »
Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation.
D. J. Gough, A. Corlett, K. Schlessinger, J. Wegrzyn, A. C. Larner, and D. E. Levy (2009)
Science 324, 1713-1716
   Abstract »    Full Text »    PDF »
Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe.
B. B. Aggarwal, R.V. Vijayalekshmi, and B. Sung (2009)
Clin. Cancer Res. 15, 425-430
   Abstract »    Full Text »    PDF »
Triterpenoid CDDO-Methyl Ester Inhibits the Janus-Activated Kinase-1 (JAK1)->Signal Transducer and Activator of Transcription-3 (STAT3) Pathway by Direct Inhibition of JAK1 and STAT3.
R. Ahmad, D. Raina, C. Meyer, and D. Kufe (2008)
Cancer Res. 68, 2920-2926
   Abstract »    Full Text »    PDF »
Immunohistochemical Analysis of Phosphotyrosine Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor Autocrine Signaling Pathways in Head and Neck Cancers and Metastatic Lymph Nodes.
R. R. Seethala, W. E. Gooding, P. N. Handler, B. Collins, Q. Zhang, J. M. Siegfried, and J. R. Grandis (2008)
Clin. Cancer Res. 14, 1303-1309
   Abstract »    Full Text »    PDF »
Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells.
A. K. Pathak, M. Bhutani, A. S. Nair, K. S. Ahn, A. Chakraborty, H. Kadara, S. Guha, G. Sethi, and B. B. Aggarwal (2007)
Mol. Cancer Res. 5, 943-955
   Abstract »    Full Text »    PDF »
Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6-Inducible STAT3 Activation.
M. Bhutani, A. K. Pathak, A. S. Nair, A. B. Kunnumakkara, S. Guha, G. Sethi, and B. B. Aggarwal (2007)
Clin. Cancer Res. 13, 3024-3032
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882