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Sci. STKE, 11 July 2006 PERSPECTIVESTouched and Moved by STAT3S. Paul Gao and Jacqueline F. Bromberg* Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. Abstract: STAT3, a member of the signal transducer and activator of transcription (STAT) family of transcription factors, is a known regulator of cell motility through its transcriptional activating functions. However, new evidence suggests a novel role for nontyrosine-phosphorylated and cytoplasmically localized STAT3 in mediating cell migration by disrupting an interaction between microtubules and one of its partners, stathmin. The association of STAT3 with stathmin potentiates microtubule polymerization and cell movement. *Corresponding author. E-mail, bromberj{at}mskcc.org
Citation: S. P. Gao, J. F. Bromberg, Touched and Moved by STAT3. Sci. STKE 2006, pe30 (2006). The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)