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Sci. STKE, 11 July 2006
Vol. 2006, Issue 343, p. pe30
[DOI: 10.1126/stke.3432006pe30]

PERSPECTIVES

Touched and Moved by STAT3

S. Paul Gao and Jacqueline F. Bromberg*

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Abstract: STAT3, a member of the signal transducer and activator of transcription (STAT) family of transcription factors, is a known regulator of cell motility through its transcriptional activating functions. However, new evidence suggests a novel role for non–tyrosine-phosphorylated and cytoplasmically localized STAT3 in mediating cell migration by disrupting an interaction between microtubules and one of its partners, stathmin. The association of STAT3 with stathmin potentiates microtubule polymerization and cell movement.

*Corresponding author. E-mail, bromberj{at}mskcc.org

Citation: S. P. Gao, J. F. Bromberg, Touched and Moved by STAT3. Sci. STKE 2006, pe30 (2006).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Triterpenoid CDDO-Methyl Ester Inhibits the Janus-Activated Kinase-1 (JAK1)->Signal Transducer and Activator of Transcription-3 (STAT3) Pathway by Direct Inhibition of JAK1 and STAT3.
R. Ahmad, D. Raina, C. Meyer, and D. Kufe (2008)
Cancer Res. 68, 2920-2926
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Immunohistochemical Analysis of Phosphotyrosine Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor Autocrine Signaling Pathways in Head and Neck Cancers and Metastatic Lymph Nodes.
R. R. Seethala, W. E. Gooding, P. N. Handler, B. Collins, Q. Zhang, J. M. Siegfried, and J. R. Grandis (2008)
Clin. Cancer Res. 14, 1303-1309
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Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells.
A. K. Pathak, M. Bhutani, A. S. Nair, K. S. Ahn, A. Chakraborty, H. Kadara, S. Guha, G. Sethi, and B. B. Aggarwal (2007)
Mol. Cancer Res. 5, 943-955
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Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6-Inducible STAT3 Activation.
M. Bhutani, A. K. Pathak, A. S. Nair, A. B. Kunnumakkara, S. Guha, G. Sethi, and B. B. Aggarwal (2007)
Clin. Cancer Res. 13, 3024-3032
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