Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 1 August 2006
Vol. 2006, Issue 346, p. tw260
[DOI: 10.1126/stke.3462006tw260]



The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] modulates a diverse array of functions related to homeostasis and responses to the environment. Despite its importance, little is known about the brain structures or the postsynaptic receptors that mediate 5-HT effects. Weisstaub et al. created 5-HT2A receptor (5-HT2AR) knockout mice and found that these animals exhibited less anxiety and more disinhibition in a conflictual situation. This behavior could be reversed by selectively restoring 5-HT2ARs in the cortex. However, restored 5-HT2AR expression in a subcortical region such as the thalamus produced no difference between rescued and knockout mice.

N. V. Weisstaub, M. Zhou, A. Lira, E. Lambe, J. González-Maeso, J.-P. Hornung, E. Sibille, M. Underwood, S. Itohara, W. T. Dauer, M. S. Ansorge, E. Morelli, J. J. Mann, M. Toth, G. Aghajanian, S. C. Sealfon, R. Hen. J. A. Gingrich, Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science 313, 536-540 (2006). [Abstract] [Full Text]

Citation: Of Mice and Fear. Sci. STKE 2006, tw260 (2006).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882