Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 29 August 2006
Vol. 2006, Issue 350, p. tw301
[DOI: 10.1126/stke.3502006tw301]


MEDICINE Diabetes: An Unfolding Story

Obesity triggers stress in the endoplasmic reticulum (ER), a network of intracellular membranes involved in protein folding and trafficking. That ER stress in turn disrupts insulin signaling. Özcan et al. investigated whether a class of small-molecule drugs that normalize ER function, called "chemical chaperones," might have therapeutic benefits in type 2 diabetes. These drugs were found to correct hyperglycemia and restore insulin sensitivity in genetically obese and diabetic mice, suggesting that they merit further study as a potential therapy for human diabetes.

U. Özcan, E. Yilmaz, L. Özcan, M. Furuhashi, E. Vaillancourt, R. O. Smith, C. Z. Görgün, G. S. Hotamisligil, Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137-1140 (2006). [Abstract] [Full Text]

Citation: Diabetes: An Unfolding Story. Sci. STKE 2006, tw301 (2006).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882