Sci. STKE, 26 September 2006
Neuroscience Beyond Self-Nonself for MHC
Pamela J. Hines
Science, AAAS, Washington, DC 20005, USA
Proteins of the major histocompatibility complex class 1 (MHC1), which are important in identifying self and nonself tissue for the immune system, are also found in the brain. Syken et al. show that a receptor, PirB, to which the MHC1 proteins bind, is also found in neurons of the brain. In mice carrying a mutant PirB lacking its signal transduction capabilities, the overall structure of the brain remained normal. However, these mice showed greater than normal plasticity in the visual cortex. Thus, intercellular signaling through PirB seems to be critical for keeping visual plasticity within limits.
Citation: P. J. Hines, Beyond Self-Nonself for MHC. Sci. STKE 2006, tw334 (2006).
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