Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 26 September 2006
Vol. 2006, Issue 354, p. tw334
[DOI: 10.1126/stke.3542006tw334]

EDITORS' CHOICE

Neuroscience Beyond Self-Nonself for MHC

Pamela J. Hines

Science, AAAS, Washington, DC 20005, USA

Proteins of the major histocompatibility complex class 1 (MHC1), which are important in identifying self and nonself tissue for the immune system, are also found in the brain. Syken et al. show that a receptor, PirB, to which the MHC1 proteins bind, is also found in neurons of the brain. In mice carrying a mutant PirB lacking its signal transduction capabilities, the overall structure of the brain remained normal. However, these mice showed greater than normal plasticity in the visual cortex. Thus, intercellular signaling through PirB seems to be critical for keeping visual plasticity within limits.

J. Syken, T. GrandPre, P. O. Kanold, C. J. Shatz, PirB restricts ocular-dominance plasticity in visual cortex. Science 313, 1795-1800 (2006). [Abstract] [Full Text]

Citation: P. J. Hines, Beyond Self-Nonself for MHC. Sci. STKE 2006, tw334 (2006).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882