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Sci. STKE, 3 October 2006
Vol. 2006, Issue 355, p. pe40
[DOI: 10.1126/stke.3552006pe40]


Gene Control by Large Noncoding RNAs

Ilya Shamovsky and Evgeny Nudler*

Department of Biochemistry, New York University Medical Center, New York, NY 10016, USA.

Abstract: Large noncoding RNAs (lncRNAs) have emerged as key players in regulating various fundamental cellular processes. Recent reports identify a functional lncRNA, Evf-2, that operates during development to control the expression of specific homeodomain proteins, and they provide important insights into the mechanism of cooperation between a newly discovered nuclear receptor co-repressor protein (SLIRP) and steroid receptor activator RNA. Evf-2 is the first example of lncRNA directly involved in organogenesis in vertebrates.

*Corresponding author. E-mail, evgeny.nudler{at}

Citation: I. Shamovsky, E. Nudler, Gene Control by Large Noncoding RNAs. Sci. STKE 2006, pe40 (2006).

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