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Sci. STKE, 3 October 2006
Vol. 2006, Issue 355, p. pe40
Gene Control by Large Noncoding RNAs
Ilya Shamovsky and
Department of Biochemistry, New York University Medical Center, New York, NY 10016, USA.
Large noncoding RNAs (lncRNAs) have emerged as key players in regulating various fundamental cellular processes. Recent reports identify a functional lncRNA, Evf-2, that operates during development to control the expression of specific homeodomain proteins, and they provide important insights into the mechanism of cooperation between a newly discovered nuclear receptor co-repressor protein (SLIRP) and steroid receptor activator RNA. Evf-2 is the first example of lncRNA directly involved in organogenesis in vertebrates.