Sci. STKE, 10 October 2006
Neuroscience Channeling Local Translation
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
Local, activity-dependent changes in excitability are thought to play a role in various aspects of neuromodulation. Translation of dendritically localized messenger RNAs is one way for a neuron to modify its excitability and signal processing machinery at or near active synapses. Raab-Graham et al. used photoconvertible fluorophores to show that potassium channels are locally translated in dendrites. This local translation is regulated by N-methyl-D-aspartate receptor activation via the mammalian target of rapamycin/phosphatidylinositol 3-kinase signaling pathway.
Citation: S. M. Hurtley, Channeling Local Translation. Sci. STKE 2006, tw348 (2006).
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