Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 10 October 2006
Vol. 2006, Issue 356, p. tw349
[DOI: 10.1126/stke.3562006tw349]

EDITORS' CHOICE

Neuroscience Anxious Mice and Men

Peter Stern

Science, AAAS, Cambridge CB2 1LQ, UK

The genes that contribute to depression and anxiety disorders are still unknown, but the recently discovered single-nucleotide polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene may be related to mood and anxiety disorders common in human populations. Chen et al. report that, in transgenic mice expressing the variant BDNFMet version, there are alterations in brain anatomy and memory as has been described in humans. This allelic variant also reproduces the phenotypic hallmarks of anxiety in humans, but these mutant mice did not respond to a common, widely used antidepressant.

Z.-Y. Chen, D. Jing, K. G. Bath, A. Ieraci, T. Khan, C.-J. Siao, D. G. Herrera, M. Toth, C. Yang, B. S. McEwen, B. L. Hempstead, F. S. Lee, Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314, 140-143 (2006). [Abstract] [Full Text]

Citation: P. Stern, Anxious Mice and Men. Sci. STKE 2006, tw349 (2006).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882