Sci. STKE, 17 October 2006
Cell Biology Dealing with DNA Damage
L. Bryan Ray
Science, Sciences STKE, AAAS, Washington, DC 20005, USA
For an organism to remain healthy, cells with damaged DNA must either pause in the cell cycle for a repair job or succumb to elimination by apoptosis. Huang et al. provide a mechanism through which cells with genomic damage may switch between these alternative fates. DNA damage activates a checkpoint signaling mechanism that arrests the cell cycle in part by inhibiting activity of cyclin-dependent kinase 2 (CDK2). The authors now find that CDK2 may also couple to the machinery controlling cell death. Normally, the transcription factor FOXO1 is phosphorylated by CDK2. In cells with extensive DNA damage, reduced phosphorylation of FOXO1 allows its translocation to the nucleus, where it enhances expression of apoptosis-inducing genes.
Citation: L. B. Ray, Dealing with DNA Damage. Sci. STKE 2006, tw359 (2006).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882