Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 31 October 2006
Vol. 2006, Issue 359, p. tw372
[DOI: 10.1126/stke.3592006tw372]


Neuroscience Herding Olfactory Axons

Pamela J. Hines

Science, AAAS, Washington, DC 20005, USA

In the mammalian olfactory system, sensory neurons each express only one odorant receptor, and the axons from neurons that express the same odorant receptor somehow manage to converge on a single glomerulus in the brain. Imai et al. have now brought both clarity and complexity to the problem. Although axon guidance was thought to depend solely on the odorant receptor, it now seems that a separate signaling system involving cyclic adenosine monophosphate (cAMP) contributes to guiding axons to a general position along the anterior-posterior axis.

T. Imai, M. Suzuki, H. Sakano, Odorant receptor-derived cAMP signals direct axonal targeting. Science 314, 657-661 (2006). [Abstract] [Full Text]

C. Dulac, Charting olfactory maps. Science 314, 606-607 (2006). [Abstract] [Full Text]

Citation: P. J. Hines, Herding Olfactory Axons. Sci. STKE 2006, tw372 (2006).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882