Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 31 October 2006
Vol. 2006, Issue 359, p. tw373
[DOI: 10.1126/stke.3592006tw373]


Neuroscience Formation of Ion Channel Complexes

Peter Stern

Science, AAAS, Cambridge CB2 1LQ, UK

Large-conductance Ca2+- and voltage-activated K+ (BKCa) channels play diverse and critical roles in a number of neuronal functions and provide a link between membrane potential and intracellular calcium. Previous studies suggested a tight functional coupling between BK channels and certain classes of voltage-gated Ca2+ channels in neurons. However, the molecular basis for such coupling has been unclear. Berkefeld et al. now confirm that BKCa channels form bimolecular complexes with voltage-gated Ca2+ channels. This bimolecular complex formation provides the basis for the fast and localized Ca2+-activated K+ signaling that controls neuronal firing patterns and release of hormones and transmitters in the central nervous system.

H. Berkefeld, C. A. Sailer, W. Bildl, V. Rohde, J.-O. Thumfart, S. Eble, N. Klugbauer, E. Reisinger, J. Bischofberger, D. Oliver, H.-G. Knaus, U. Schulte, B. Fakler, BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Science 314, 615-620 (2006). [Abstract] [Full Text]

Citation: P. Stern, Formation of Ion Channel Complexes. Sci. STKE 2006, tw373 (2006).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882