Sci. STKE, 31 October 2006
Cell Biology Ring Around the Spindle Checkpoint
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
The molecular role of the centrosome in the spindle checkpoint has been debated for some time. Müller et al. have now identified a function for a subset of core centrosomal proteins, namely their involvement in the spindle checkpoint. -tubulin ring proteins are functionally and biochemically integrated into checkpoint control, together with two of the major players in this pathway, BubR1 and Cdc20. However, the function of the -tubulin ring components was not linked to centrosome integrity, nor did it require localization to this organelle.
H. Müller, M.-L. Fogeron, V. Lehmann, H. Lehrach, B. M. H. Lange, A centrosome-independent role for -TuRC proteins in the spindle assembly checkpoint. Science 314, 654-657 (2006). [Abstract] [Full Text]
Citation: S. M. Hurtley, Ring Around the Spindle Checkpoint. Sci. STKE 2006, tw375 (2006).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882