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Sci. STKE, 7 November 2006 PERSPECTIVESStress-ING Out: Phosphoinositides Mediate the Cellular Stress ResponseMatthew W. Bunce, Michael L. Gonzales, and Richard A. Anderson* Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA. Abstract: Phosphoinositides regulate numerous cellular processes required for growth, proliferation, and motility. Whereas phosphoinositide signal transduction pathways within the cytosol have been well characterized, nuclear signaling pathways remain poorly understood. Accumulating experimental data have now started to uncover critical functions for nuclear phosphoinositides. In particular, phosphoinositides modulate the activity of the tumor suppressor protein ING2 in response to extracellular stress. These findings highlight a previously uncharacterized function for phosphoinositides and implicate their metabolism in signaling pathways critical for cell survival. *Corresponding author. E-mail, raanders{at}wisc.edu
Citation: M. W. Bunce, M. L. Gonzales, R. A. Anderson, Stress-ING Out: Phosphoinositides Mediate the Cellular Stress Response. Sci. STKE 2006, pe46 (2006). The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
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