Sci. STKE, 7 November 2006
Neuroscience Neurite Extension and Membrane Trafficking
Stella M. Hurtley
Science, AAAS, Cambridge CB2 1LQ, UK
Neurons extend processes (neurites) that can reach more than 1 meter in length. Formation of neurites requires both cytoskeletal remodeling and membrane transport. Shirane and Nakayama have now identified a protein, protrudin, that is essential for neurite extension triggered by nerve growth factor. Protrudin binds to and inhibits the activity of the protein Rab11, which functions as a molecular switch in membrane transport to the cell surface.
Citation: S. M. Hurtley, Neurite Extension and Membrane Trafficking. Sci. STKE 2006, tw379 (2006).
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