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Sci. STKE, 7 November 2006
Vol. 2006, Issue 360, p. tw379
[DOI: 10.1126/stke.3602006tw379]

EDITORS' CHOICE

Neuroscience Neurite Extension and Membrane Trafficking

Stella M. Hurtley

Science, AAAS, Cambridge CB2 1LQ, UK

Neurons extend processes (neurites) that can reach more than 1 meter in length. Formation of neurites requires both cytoskeletal remodeling and membrane transport. Shirane and Nakayama have now identified a protein, protrudin, that is essential for neurite extension triggered by nerve growth factor. Protrudin binds to and inhibits the activity of the protein Rab11, which functions as a molecular switch in membrane transport to the cell surface.

M. Shirane, K. I. Nakayama, Protrudin induces neurite formation by directional membrane trafficking. Science 314, 818-821 (2006). [Abstract] [Full Text]

Citation: S. M. Hurtley, Neurite Extension and Membrane Trafficking. Sci. STKE 2006, tw379 (2006).


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