Sci. STKE, 7 November 2006
Aging A Cool Way to a Long Life
Paula A. Kiberstis
Science, AAAS, Washington, DC 20005, USA
Caloric dietary restriction prolongs life span in a variety of organisms, and in mammals, the resultant lowering of core body temperature has been offered as one potential explanation. Conti et al. generated transgenic mice that overexpress mitochondrial uncoupling protein 2 in hypocretin-producing neurons within the hypothalamus, which lowers core body temperature by about 0.5ºC. In the absence of caloric restriction, the median life span of these "cool mice" was about 15% greater than that of their wild-type littermates.
B. Conti, M. Sanchez-Alavez, R. Winsky-Sommerer, M. C. Morale, J. Lucero, S. Brownell, V. Fabre, S. Huitron-Resendiz, S. Henriksen, E. P. Zorrilla, L. de Lecea, T. Bartfai, Transgenic mice with a reduced core body temperature have an increased life span. Science 314, 825-828 (2006). [Abstract] [Full Text]
Citation: P. A. Kiberstis, A Cool Way to a Long Life. Sci. STKE 2006, tw383 (2006).
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