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Sci. STKE, 12 December 2006
Vol. 2006, Issue 365, p. pe51
[DOI: 10.1126/stke.3652006pe51]

PERSPECTIVES

What Is So Special About Oskar Wild?

William O’Gorman and Alexandre Akoulitchev*

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

Abstract: The amazing world of regulatory noncoding RNA has been at the center of biologists’ attention in many different fields, from structural biology to transcriptional regulation and cell signaling. The latest example comes from developmental biology. A mutation in the Drosophila gene Oskar reveals a novel developmental function for the 3' untranslated region (UTR) of the oscar mRNA. This study further suggests that, when transcribed, the noncoding parts of the genome may well carry essential regulatory functions fundamental for the coordinated gene expression and development of multicellular organisms.

*Corresponding author. E-mail: alexandre.akoulitchev{at}path.ox.ac.uk

Citation: W. O’Gorman, A. Akoulitchev, What Is So Special About Oskar Wild? Sci. STKE 2006, pe51 (2006).

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