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Sci. STKE, 19 December 2006
Vol. 2006, Issue 366, p. pe53
[DOI: 10.1126/stke.3662006pe53]

PERSPECTIVES

Intermediate Filaments as Signaling Platforms

Hanna-Mari Pallari1,2 and John E. Eriksson1,3*

1Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Post Office Box 123, FIN- 20521 Turku, Finland.
2Department of Biology, University of Turku, Science Building 1, FIN-20014 Turku, Finland.
3Department of Biology, Åbo Akademi University, Tykistökatu 6B, FIN-20520 Turku, Finland.

Abstract: Intermediate filaments (IFs) are cytoskeletal structures that are crucial for maintaining the structural and mechanical integrity of cells and tissues. Intriguingly, a wide range of previously unknown nonmechanical roles for the IF cytoskeleton are emerging: Recent studies have linked IFs to the integration of signals related to the determination of cell size, the regulation of cell migration and cell survival, and the buffering of the effects of stress-activated kinases. The characteristic structural features and expression patterns of the different members of this diverse family of highly abundant proteins make them well suited to act as cell- and tissue-specific modifiers and organizers of signaling.

*Corresponding author. Department of Biology, Åbo Akademi University, Tykistökatu 6B, FIN-20520 Turku, Finland. Telephone, 358-2-333-8036; fax, 333-2-333-8000; e-mail, john.eriksson{at}btk.fi

Citation: H.-M. Pallari, J. E. Eriksson, Intermediate Filaments as Signaling Platforms. Sci. STKE 2006, pe53 (2006).

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