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Sci. STKE, 16 January 2007
Vol. 2007, Issue 369, p. tw23
[DOI: 10.1126/stke.3692007tw23]

EDITORS' CHOICE

Immunology Separate Ways

Stephen Simpson

Science, AAAS, Cambridge CB2 1LQ, UK

Two dominant lineages of T cells ({alpha}beta and {gamma}{delta} T cells) are highly distinct in function and anatomical location yet share a common precursor within the thymus. Exactly how one cell fate is decided over another remains unresolved. Melichar et al. present evidence that selection to the {gamma}{delta} T cell branch in the thymus is controlled by the transcription factor SOX13, which supports and possibly even initiates {gamma}{delta} T cell development while opposing differentiation of their {alpha}beta T cell brethren. The authors noted that SOX13 inhibited an important effector of the central T cell developmental signaling pathway mediated by the Wnt protein.

H. J. Melichar, K. Narayan, S. D. Der, Y. Hiraoka, N. Gardiol, G. Jeannet, W. Held, C. A. Chambers, J. Kang, Regulation of {gamma}{delta} versus {alpha}beta T lymphocyte differentiation by the transcription factor SOX13. Science 315, 230-233 (2007). [Abstract] [Full Text]

Citation: S. Simpson, Separate Ways. Sci. STKE 2007, tw23 (2007).

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