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Sci. STKE, 23 January 2007
Vol. 2007, Issue 370, p. pe3
[DOI: 10.1126/stke.3702007pe3]

PERSPECTIVES

Propping Up Our Knowledge of G Protein Signaling Pathways: Diverse Functions of Putative Noncanonical Gbeta Subunits in Fungi

Charles S. Hoffman*

Biology Department, Boston College, Chestnut Hill, MA 02467, USA.

Abstract: Heterotrimeric guanine nucleotide–binding proteins, composed of G{alpha}, Gbeta, and G{gamma} subunits, are important mediators of fungal pheromone and nutrient signaling pathways. Most fungal genomes encode two or three functionally distinct G{alpha} subunits but only a single canonical Gbeta subunit, which does not bind multiple G{alpha} subunits. Studies in Saccharomyces cerevisiae, Cryptococcus neoformans, and Schizosaccharomyces pombe have identified binding partners for G{alpha} subunits, which are proposed to be "noncanonical Gbeta subunits." This Perspective reviews these studies, summarizing the strengths and weaknesses of the claims to this designation for these four fungal proteins.

*Contact information. E-mail, hoffmacs{at}bc.edu

Citation: C. S. Hoffman, Propping Up Our Knowledge of G Protein Signaling Pathways: Diverse Functions of Putative Noncanonical Gbeta Subunits in Fungi. Sci. STKE 2007, pe3 (2007).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)