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Sci. STKE, 30 January 2007
Vol. 2007, Issue 371, p. tw38
[DOI: 10.1126/stke.3712007tw38]

EDITORS' CHOICE

Development Making the Gradient

Stella M. Hurtley

Science, AAAS, Cambridge CB2 1LQ, UK

The role of gradients of morphogens in developmental biology is well established, but the mechanisms involved in the establishment and maintenance of these gradients are controversial. Kicheva et al. present a quantitative study of the kinetics of morphogen transport and the formation of morphogen gradients in the wing disc of Drosophila. The steady-state gradients of two morphogens can be described by a simple exponential decay defined by four key kinetic parameters.

A. Kicheva, P. Pantazis, T. Bollenbach, Y. Kalaidzidis, T. Bittig, F. Jülicher, M. González-Gaitán, Kinetics of morphogen gradient formation. Science 315, 521-525 (2007). [Abstract] [Full Text]

Citation: S. M. Hurtley, Making the Gradient. Sci. STKE 2007, tw38 (2007).


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