Sci. STKE, 30 January 2007
Immunology Inside B Cell Central
Science, AAAS, Cambridge CB2 1LQ, UK
B cells become effective factories for antibody production only after they have gone through a series of maturation steps that select clones of B cells carrying somatic mutations for high-affinity antibody. This process takes place in the germinal center, where B cells are also thought to compete vigorously for available antigen. Using intravital microscopy, Allen et al. observed that the behavior of germinal center B cells is more consistent with a competition for the attention of helper T cells than for scarce antigen. This finding could prove useful in considering how best to stimulate robust immune responses with vaccines.
Citation: S. Simpson, Inside B Cell Central. Sci. STKE 2007, tw39 (2007).
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