Sci. STKE, 30 January 2007
Development Exploiting Your Niche
Science, AAAS, Washington, DC 20005, USA
In Drosophila, male germ line stem cells orient the mitotic spindle to generate a daughter stem cell and a cell destined for germ cell differentiation after asymmetric cell division. Using gene mutation and ultrastructural studies, Yamashita et al. (see also the Perspective by Spradling and Zheng) now identify the mechanism by which the oriented spindle is established. The mother and daughter centrosomes are differentially oriented, with the mother centrosome anchored close to the niche-stem cell junction by microtubules, whereas the daughter centrosome migrates to the other side of the cell. This differential centrosome identity and migration may provide a mechanism for asymmetric cell division in the generation of daughter cells with different developmental fates.
Citation: B. Purnell, Exploiting Your Niche. Sci. STKE 2007, tw40 (2007).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882