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Sci. STKE, 6 February 2007
Vol. 2007, Issue 372, p. tw41
[DOI: 10.1126/stke.3722007tw41]

EDITORS' CHOICE

G Protein-Coupled Receptors Diversifying Role for beta-Arrestin

L. Bryan Ray

Science, Science’s STKE, AAAS, Washington, DC 20005, USA

Intense investigation is focused on understanding mechanisms that control signaling through G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors (GPCRs), because they are known to be productive targets for therapeutic drugs. Nelson et al. show that beta-arrestins, which limit signaling by GPCRs coupled to G proteins of the Gs class, serve a very similar function in control of signaling by M1 muscarinic receptors. The muscarinic receptors use a different class of G protein linked to distinct signaling machinery.

C. D. Nelson, S. J. Perry, D. S. Regier, S. M. Prescott, M. K. Topham, R. J. Lefkowitz, Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science 315, 663-666 (2007). [Abstract] [Full Text]

E. F. Grady, beta-Arrestin, a two-fisted terminator. Science 315, 605-606 (2007). [Summary] [Full Text]

Citation: L. B. Ray, Diversifying Role for beta-Arrestin. Sci. STKE 2007, tw41 (2007).


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