Sci. STKE, 20 February 2007
Development And Then There Were Three
Pamela J. Hines
Science, AAAS, Washington, DC 20005, USA
During development, stem cells usually generate one daughter cell that differentiates and another stem cell. Ohlstein and Spradling now describe a type of stem cell in the Drosophila intestine that produces three offspring fates--a stem cell, an enterocyte, and an enteroendocrine cell. The choice in fate seems to depend on the amount of the protein Delta (which can activate the signaling receptor Notch) that is expressed in the stem cell at cell division. Daughter cells with high amounts of Delta-Notch signaling become enterocytes, those with lower amounts become enteroendocrine cells, and those with the least amount retain the stem cell fate.
Citation: P. J. Hines, And Then There Were Three. Sci. STKE 2007, tw61 (2007).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882