Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 20 February 2007
Vol. 2007, Issue 374, p. tw62
[DOI: 10.1126/stke.3742007tw62]

EDITORS' CHOICE

Microbiology Lethal Injection

Stella M. Hurtley

Science, AAAS, Cambridge CB2 1LQ, UK

Pathogenic bacteria can inject into host cells virulence factors via the so-called type III machinery. Li et al. describe a family of bacterial virulence factors that have a previously unknown phosphothreonine lyase activity that can remove the phosphate from signaling mitogen-activated protein kinase family members involved in innate immunity. This family of effectors is important in the virulence of a variety of animal and plant bacterial pathogens, including Shigella, Salmonella, and Pseudomonas syringae.

H. Li, H. Xu, Y. Zhou, J. Zhang, C. Long, S. Li, S. Chen. J.-M. Zhou, F. Shao, The phosphothreonine lyase activity of a bacterial type III effector family. Science 315, 1000-1003 (2007). [Abstract] [Full Text]

Citation: S. M. Hurtley, Lethal Injection. Sci. STKE 2007, tw62 (2007).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882