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Sci. STKE, 20 February 2007
Vol. 2007, Issue 374, p. tw63
[DOI: 10.1126/stke.3742007tw63]

EDITORS' CHOICE

Medicine Joint Effort

Stephen Simpson

Science, AAAS, Cambridge CB2 1LQ, UK

Rheumatoid arthritis (RA) is an autoimmune condition that leads to joint inflammation. Lee et al. (see the Perspective by Firestein) identify a new regulator of the cellular organization of the synovium that might also provide a potential therapeutic target for inflammatory arthritis. Mice lacking the cell adhesion molecule cadherin-11 showed significantly reduced growth of the synovium and were resistant to the development of an experimentally induced RA-like condition. Joint inflammation in mice could be inhibited with a monoclonal antibody to cadherin-11.

D. M. Lee, H. P. Kiener, S. K. Agarwal, E. H. Noss, G. F. M. Watts, O. Chisaka, M. Takeichi, M. B. Brenner, Cadherin-11 in synovial lining formation and pathology in arthritis. Science 315, 1006-1010 (2007). [Abstract] [Full Text]

G. S. Firestein, Every joint has a silver lining. Science 315, 952-953 (2007). [Summary] [Full Text]

Citation: S. Simpson, Joint Effort. Sci. STKE 2007, tw63 (2007).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)