Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 20 February 2007
Vol. 2007, Issue 374, p. tw64
[DOI: 10.1126/stke.3742007tw64]

EDITORS' CHOICE

Cell Biology Sticky Fingers

Stella M. Hurtley

Science, AAAS, Cambridge CB2 1LQ, UK

As animal cells migrate across a surface, they send out processes known as filopodia that explore the substratum. Galbraith et al. now find that the intracellular actin network directs very local protrusions that contain clusters of cell surface-adhesion molecules at their tips that are primed to interact with molecules of the extracellular matrix. These "sticky fingers" at the leading edge of motile cells appear to search for suitable sites of adhesion that can then be used to help move the rest of the cell.

C. G. Galbraith, K. M. Yamada, J. A. Galbraith, Polymerizing actin fibers position integrins primed to probe for adhesion sites. Science 315, 992-995 (2007). [Abstract] [Full Text]

Citation: S. M. Hurtley, Sticky Fingers. Sci. STKE 2007, tw64 (2007).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882