Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 13 March 2007
Vol. 2007, Issue 377, p. tw90
[DOI: 10.1126/stke.3772007tw90]

EDITORS' CHOICE

Molecular Biology Changing the Histone Landscape

Guy Riddihough

Science, AAAS, Washington, DC 20005, USA

In eukaryotes, histone proteins help package DNA into chromatin. Marks or covalent modifications on histones play an important role in the epigenetic regulation of gene expression, as well as DNA replication and repair. It has been assumed that the histones within chromatin will be fairly stable. Mito et al. and Dion et al. instead show that for certain regions of the genome in yeast and in Drosophila, there is a dramatic variation in histone H3 turnover rates. Coding regions in the genome were unexpectedly "quiet," and protein binding sites in promoters--and especially boundary elements--showed a very high level of turnover. In regions of high turnover, epigenetic marks must be in a state of constant flux, which provides the potential for their rapid and dynamic regulation.

Y. Mito, J. G. Henikoff, S. Henikoff, Histone replacement marks the boundaries of cis-regulatory domains. Science 315, 1408-1411 (2007). [Abstract] [Full Text]

M. F. Dion, T. Kaplan, M. Kim, S. Buratowski, N. Friedman, O. J. Rando, Dynamics of replication-independent histone turnover in budding yeast. Science 315, 1405-1408 (2007). [Abstract] [Full Text]

Citation: G. Riddihough, Changing the Histone Landscape. Sci. STKE 2007, tw90 (2007).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882