Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Focus on Europe

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 20 March 2007
Vol. 2007, Issue 378, p. tw96
[DOI: 10.1126/stke.3782007tw96]

EDITORS' CHOICE

Medicine Keeping Things Quiet

Stephen Simpson

Science, AAAS, Cambridge CB2 1LQ, UK

Among its many functions, RNA silencing provides broad cellular defense against viruses in many plant and animal species. To perform defense functions, microRNAs (miRNAs) arm an RNA-induced silencing complex (RISC), which either degrades messenger RNA or inhibits its translation. Triboulet et al. show that proteins responsible for generating miRNA potently inhibit human immunodeficiency virus-type 1 (HIV-1) in naturally infected cells and that HIV-1 counters this by down-modulating the expression of selected cellular miRNAs to favor replication. Targeting the miRNA processing pathway may offer a strategy for activating latent viral reservoirs, which remain barriers to eliminating chronic HIV-1 infection.

R. Triboulet, B. Mari, Y.-L. Lin, C. Chable-Bessia, Y. Bennasser, K. Lebrigand, B. Cardinaud, T. Maurin, P. Barbry, V. Baillat, J. Reynes, P. Corbeau, K.-T. Jeang, M. Benkirane, Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science 315, 1579-1582 (2007). [Abstract] [Full Text]

Citation: S. Simpson, Keeping Things Quiet. Sci. STKE 2007, tw96 (2007).

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)