Sci. STKE, 20 March 2007
Medicine Keeping Things Quiet
Science, AAAS, Cambridge CB2 1LQ, UK
Among its many functions, RNA silencing provides broad cellular defense against viruses in many plant and animal species. To perform defense functions, microRNAs (miRNAs) arm an RNA-induced silencing complex (RISC), which either degrades messenger RNA or inhibits its translation. Triboulet et al. show that proteins responsible for generating miRNA potently inhibit human immunodeficiency virus-type 1 (HIV-1) in naturally infected cells and that HIV-1 counters this by down-modulating the expression of selected cellular miRNAs to favor replication. Targeting the miRNA processing pathway may offer a strategy for activating latent viral reservoirs, which remain barriers to eliminating chronic HIV-1 infection.
R. Triboulet, B. Mari, Y.-L. Lin, C. Chable-Bessia, Y. Bennasser, K. Lebrigand, B. Cardinaud, T. Maurin, P. Barbry, V. Baillat, J. Reynes, P. Corbeau, K.-T. Jeang, M. Benkirane, Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science 315, 1579-1582 (2007). [Abstract] [Full Text]
Citation: S. Simpson, Keeping Things Quiet. Sci. STKE 2007, tw96 (2007).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882