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Sci. STKE, 3 April 2007
Vol. 2007, Issue 380, p. pe12
[DOI: 10.1126/stke.3802007pe12]
PERSPECTIVES
Fat Flies Expanded the Hippo Pathway: A Matter of Size Control
Feng Yin and
Duojia Pan*
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Abstract:
By simultaneously inhibiting cell proliferation while promoting apoptosis, the Hippo signaling pathway provides a robust mechanism to restrict organ size during Drosophila development. Despite impressive progress in revealing the key intracellular components of this growth-regulatory pathway, the nature of the signal that regulates Hippo signaling in vivo has remained elusive. Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu.
*Corresponding author: E-mail, djpan{at}jhmi.edu
Citation: F. Yin, D. Pan, Fat Flies Expanded the Hippo Pathway: A Matter of Size Control. Sci. STKE2007, pe12 (2007).
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