Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 3 April 2007
Vol. 2007, Issue 380, p. pe12
[DOI: 10.1126/stke.3802007pe12]

PERSPECTIVES

Fat Flies Expanded the Hippo Pathway: A Matter of Size Control

Feng Yin and Duojia Pan*

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract: By simultaneously inhibiting cell proliferation while promoting apoptosis, the Hippo signaling pathway provides a robust mechanism to restrict organ size during Drosophila development. Despite impressive progress in revealing the key intracellular components of this growth-regulatory pathway, the nature of the signal that regulates Hippo signaling in vivo has remained elusive. Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu.

*Corresponding author: E-mail, djpan{at}jhmi.edu

Citation: F. Yin, D. Pan, Fat Flies Expanded the Hippo Pathway: A Matter of Size Control. Sci. STKE 2007, pe12 (2007).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation.
J.-H. Kim and A. R. Asthagiri (2011)
J. Cell Sci. 124, 1280-1287
   Abstract »    Full Text »    PDF »
14-3-3{sigma} Controls Corneal Epithelium Homeostasis and Wound Healing.
Q. Lu, Y. Xin, F. Ye, G. Foulks, and Q. Li (2011)
Invest. Ophthalmol. Vis. Sci. 52, 2389-2396
   Abstract »    Full Text »    PDF »
Regulation of leg size and shape by the Dachsous/Fat signalling pathway during regeneration.
T. Bando, T. Mito, Y. Maeda, T. Nakamura, F. Ito, T. Watanabe, H. Ohuchi, and S. Noji (2009)
Development 136, 2235-2245
   Abstract »    Full Text »    PDF »
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
B. Zhao, X. Wei, W. Li, R. S. Udan, Q. Yang, J. Kim, J. Xie, T. Ikenoue, J. Yu, L. Li, et al. (2007)
Genes & Dev. 21, 2747-2761
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882