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Sci. STKE, 3 April 2007
Vol. 2007, Issue 380, p. pe12
[DOI: 10.1126/stke.3802007pe12]


Fat Flies Expanded the Hippo Pathway: A Matter of Size Control

Feng Yin and Duojia Pan*

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract: By simultaneously inhibiting cell proliferation while promoting apoptosis, the Hippo signaling pathway provides a robust mechanism to restrict organ size during Drosophila development. Despite impressive progress in revealing the key intracellular components of this growth-regulatory pathway, the nature of the signal that regulates Hippo signaling in vivo has remained elusive. Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu.

*Corresponding author: E-mail, djpan{at}

Citation: F. Yin, D. Pan, Fat Flies Expanded the Hippo Pathway: A Matter of Size Control. Sci. STKE 2007, pe12 (2007).

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