Focus Issue: Exploring New Avenues for Cancer Treatment

Elizabeth M. Adler^1* and Nancy R. Gough²

¹ Associate Editor of Science's STKE,
²Editor of Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: This issue of Science’s STKE features research into the pathophysiology of cancer cells. The featured articles describe how malignancy may arise due to the subversion of normal cellular functions, the signaling pathways involved, and new approaches to cancer therapy that involve the exploitation of oncogenic changes. The research presented provides an optimistic outlook for translating new understanding of cell signaling into novel therapies.

*Corresponding author. E-mail: eadler{at}aaas.org.

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
Cancer
Increasing Imatinib Efficacy with Immunotherapy

Heather M. Thompson (20 September 2011)
Sci. Signal. 4 (191), ec261. [DOI: 10.1126/scisignal.4191ec261]
 |  Abstract »

EDITORS' CHOICE
Apoptosis
Death by Acetylation

Nancy R. Gough (23 August 2011)
Sci. Signal. 4 (187), ec231. [DOI: 10.1126/scisignal.4187ec231]
 |  Abstract »

EDITORIAL GUIDES
Cancer
Focus Issue: Rendering Resistance Futile

Elizabeth M. Adler and Nancy R. Gough (29 March 2011)
Sci. Signal. 4 (166), eg3. [DOI: 10.1126/scisignal.2002014]
 |  Abstract »  |  Full Text »  |  PDF »

EDITORS' CHOICE
Cancer
Tumor Suppression Through Metabolic Regulation

Nancy R. Gough (27 April 2010)
Sci. Signal. 3 (119), ec126. [DOI: 10.1126/scisignal.3119ec126]
 |  Abstract »

EDITORS' CHOICE
Cancer Metabolism
High Fat Content

John F. Foley (12 January 2010)
Sci. Signal. 3 (104), ec8. [DOI: 10.1126/scisignal.3104ec8]
 |  Abstract »

EDITORS' CHOICE
Pharmacology
Targeting the Resistance

Nancy R. Gough (5 January 2010)
Sci. Signal. 3 (103), ec1. [DOI: 10.1126/scisignal.3103ec1]
 |  Abstract »

RESEARCH ARTICLES
Cancer Biology
Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction

Andrea Bertotti, Mike F. Burbridge, Stefania Gastaldi, Francesco Galimi, Davide Torti, Enzo Medico, Silvia Giordano, Simona Corso, Gaëlle Rolland-Valognes, Brian P. Lockhart, John A. Hickman, Paolo M. Comoglio, and Livio Trusolino (8 December 2009)
Sci. Signal. 2 (100), ra80. [DOI: 10.1126/scisignal.2000643]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

EDITORS' CHOICE
Cancer
Endogenous Angiogenesis Inhibition

Elizabeth M. Adler (30 June 2009)
Sci. Signal. 2 (77), ec215. [DOI: 10.1126/scisignal.277ec215]
 |  Abstract »

PODCASTS
Medicine
Science Signaling Podcast: 07 April 2009

Brendan D. Manning and Annalisa M. VanHook (7 April 2009)
Sci. Signal. 2 (65), pc7. [DOI: 10.1126/scisignal.265pc7]
 |  Abstract »  |  Full Text »  |  Podcast »