Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 10 April 2007
Vol. 2007, Issue 381, p. tw128
[DOI: 10.1126/stke.3812007tw128]

EDITORS' CHOICE

Genetics Sizing Up Man’s Best Friend

Paula A. Kiberstis

Science, AAAS, Washington, DC 20005, USA

In contrast to most mammalian species, Canis familiaris (the domestic dog) shows extreme diversity in body size. Sutter et al. show that a single allele of the gene encoding insulin-like growth factor-1 (IGF-1) is shared by all small dog breeds but is nearly absent from giant dog breeds, implying that sequence variation in the IGF-1 gene plays a causal role in dog size. Discovery of the IGF-1 gene was facilitated by its localization within a genomic signature, or haplotype block, that probably arose as a result of centuries of dog breeding by humans.

N. B. Sutter, C. D. Bustamante, K. Chase, M. M. Gray, K. Zhao, L. Zhu, B. Padhukasahasram, E. Karlins, S. Davis, P. G. Jones, P. Quignon, G. S. Johnson, H. G. Parker, N. Fretwell, D. S. Mosher, D. F. Lawler, E. Satyaraj, M. Nordborg, K. G. Lark, R. K. Wayne, E. A. Ostrander, A single IGF1 allele is a major determinant of small size in dogs. Science 316, 112-115 (2007). [Abstract] [Full Text]

Citation: P. A. Kiberstis, Sizing Up Man’s Best Friend. Sci. STKE 2007, tw128 (2007).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882